Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the (...) right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs. (shrink)

The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

Svirsky, Howard, and Berman have enumerated a variety of U.S. FDA roles, arguing that although the public possess a “right to information” about health risks,...

ObjectivesAbnormal brain function in ASD patients changes dynamically across developmental stages. However, no one has studied the brain function of prepubertal children with ASD. Prepuberty is an important stage for children’s socialization. This study aimed to investigate alterations in local spontaneous brain activity in prepubertal boys with ASD.Materials and MethodsMeasures of the amplitude of low-frequency fluctuations and regional homogeneity acquired from resting-state functional magnetic resonance imaging database, including 34 boys with ASD and 49 typically developing boys aged 7 to 10 (...) years, were used to detect regional brain activity. Pearson correlation analyses were conducted on the relationship between abnormal ALFF and ReHo values and Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised scores.ResultsIn the ASD group, we found decreased ALFF in the left inferior parietal lobule and decreased ReHo in the left lingual gyrus, left superior temporal gyrus, left middle occipital gyrus, and right cuneus. There were negative correlations between ReHo values in the left LG and left STG and the ADOS social affect score and a negative correlation between ReHo values in the left STG and the calibrated severity total ADOS score.ConclusionBrain regions with functional abnormalities, including the left IPL, left LG, left STG, left MOG, and right cuneus may be crucial in the neuropathology of prepubertal boys with ASD. Furthermore, ReHo abnormalities in the left LG and left STG were correlated with sociality. These results will supplement the study of neural mechanisms in ASD at different developmental stages, and be helpful in exploring the neural mechanisms of prepubertal boys with ASD. (shrink)

To address the need for a valid and reliable scale of youth leadership potential based on the development theory of leadership, the current study developed the Youth Leadership Potential Scale (YLPS) and investigated its factor structure and psychometric properties in a sample of 696 students (grades 7-9) in China. Exploratory structural equation modeling (ESEM) identified a five-factor solution comprising leadership information, leadership attitude, communication skills, decision-making skills, and stress management skills. ESEM within confirmatory factor analysis demonstrated an adequate fit for (...) this structure. The scale showed good composite reliability and measurement invariance across different gender and grade/age groups. The scale also showed sufficient concurrent validity with the Coping Self-Efficacy Scale, the Chinese Roets Rating Scale for Leadership, and the Leadership Skills Inventory. Furthermore, criterion-related validity was supported by the relationship between YLPS scores and the length of student leadership positions. The results suggest that the YLPS is a valid and pragmatic measure for assessing youth leadership potential. The current study is the first to develop a youth leadership potential scale based on the development theory of leadership. (shrink)

ObjectivesAcupuncture therapy has been used for cognitive impairment-related diseases, however, there are still few studies on the overall trend of acupuncture therapy on cognitive impairment based on bibliometric analysis. The purpose of this study was to explore the research trend of the impact of acupuncture on cognitive impairment in the past 15 years, analyze the research trends and hotspots, and provide new ideas and theoretical basis for future research directions.MethodsFrom the Web of Science Core Collection, the relevant literature on the (...) treatment of cognitive impairment with acupuncture from 2007 to 2022 was retrieved. Then, based on the CiteSpace and VOSviewer software of the Java platform, the cooperation between countries and institutions in this field, the co-citation of journals and documents, and the cooperation between authors and authors, etc. were analyzed. In addition, the co-occurrence and burst analysis of keywords are also carried out, and a visual knowledge map is drawn.ResultsAs of August 08, 2022, a total of 394 records related to the treatment of cognitive impairment with acupuncture were identified. The analysis results show: The number and rate of annual publications have steadily increased, with some fluctuations from year to year. The countries that contribute the most to this field are China and the USA. Among them, Beijing University of Chinese Medicine and Capital Medical University are tied for first place in terms of the number of published papers. Tao Jing is the most prolific author and the number one cited author.ConclusionsThe number of publications on acupuncture for cognitive impairment is expected to increase rapidly in future research, suggesting a bright future for the field. Future research hotspots will focus on pain, injury, protocol, diagnosis, guidelines, etc. It is also necessary to strengthen cross-regional and cross-country cooperation among various academic groups. (shrink)

本书结合对马克思、恩格斯哲学原著的研究探讨,对大学生们在学习中提出的若干问题进行了阐释。.

本书对自组织理论进行综合性研究,并探讨了关于自然界自组织演化的自然图景和自然观,关于自然科学自组织演化的科学图景和科学观。.

本书通过事例告诉人们美的灵感究竟是怎样产生的,怎样了解审美意识的心理过程和心理结构等。.

本书在透过“现代性”和“审美教育”这一视角,采用文化学、心理学和美学相结合的方法,透过有关现代性和审美教育言说的复杂性和矛盾,既以现代性和审美教育的言说为基础,又要跳出已有的言说:既体会西方现代性论者 和审美教育论者的言内言外之意,又超越西方学者用以进行表述的西文的局限,力图从丰富、复杂、矛盾的现代性言说和审美教育言说的迷宫里清理出其内在意识中所欲表达的东西.

Researchers tend to believe that bamboo "I" more concerned about practical, and more on the ruler the people rule the country road, or self-cultivation and the country contains only two types of content, rarely discussed cosmology and Dao. However, analysis of this article pointed out, Guodian bamboo "I", although incomplete because of missing, can not present a complete and systematic channel theory and cosmology, but such ideas are still very clear. Which show more about all things back to the text (...) attributed to road, but more the lack of road itself, and discussion of all things produced by the channel. However, in the nature of the road, bamboo so-called "independent non-hai" means nothing big road boundaries, more reasonable, if not more than this as a "stand-alone does not change," stressed the same channel and into the road easily and dynamic nature of the eternal confrontation between the problem. Bamboo "I" because of the Confucian interpretation of the impact of personnel or political considerations may intervene in the Road, or the textual representation of the universe, such as "WANG Yi-big", "there are four countries, Yan Wang Ju," and other statements, highlight the "King "The existence of taxonomic status, the personnel and the existence of confusion. Sometimes, however, the influence of Confucianism can also help some of the papers in this universe purification, such as bamboo, "I," a the "between heaven and earth, and its initiatives and abandoned Yue? True and unyielding moving, but more out." period, less the object of Confucian benevolence few words of text and teaching people's advice, but more simply to save the universe in which this paper, I highlighted more clearly Bing empty space on the dynamic. For the interpretation of Confucian bamboo "I" "Germany" and "view" a greater impact on the basic concepts. "German" in the other book is a cosmological concept of the Central Plains; but in the bamboo in the "virtue" is only for people. As for the "concept" in the rest of all this in view of all things can be reverted to, as well as view the body, view home, view of town and watch the state and watch the world, but in bamboo, "I", only for the personnel of various units of the view layer, without of the "body" and "things" concept. "Concept" became the method applies only to personnel, lost cosmological meaning. The earliest manuscripts date Guodian bamboo corporations, but neither is the only transcript, it is difficult to convince me to the nearest original. One kind of transcript is often a kind of interpretation of the text lead to ideas, and ideas for all of the text should be text data. Guodian bamboo "I" is only just a sympathizer of the transcript from the Confucian, in addition, there are other more dollars transcript "instead of allowing" close to the original "ideas that shape our interpretation of a text, it is better to keep" multiple text "idea , open minded, so that each text have encountered trigger contemplation, thinking of the rich gain. The Guodian Bamboo Texts of Lao Zi, discovered in 1993, though the earliest texts we now possess, do not give support to the idea of ​​a linear development from Kuodian Texts to Silk texts, then from Silk texts to other texts such as those of Wang Bi among others'. I contend the concept of "multiple texts", in which the copying of texts or the integration of one text in a collection of texts could be thought of as inevitably imbued with interpretations. The Guodian Bamboo Texts of Lao Zi were susceptible to Confucian or pro-Confucian interpretations, by which not only those critiques of Confucian basic concepts such as Ren and Yi were minimized, but also the Taoist ontology and cosmology were thereby affected. Many scholars sustain the position that Guodian Lao Zi were more pragmatically oriented or that they contained only two categories of thought, one about self-cultivation, another about the art of governing, whereas the discourse on Dao and cosmology were neglected. But I demonstrate in this paper that the Guodian texts, though incomplete in themselves, still gave us very clear ideas of a discourse on Tao and a cosmology. In general, the Guodian Lao Zi emphasized more the way by which all things return to Dao, rather than on Tao itself and its process of producing all things. Concerning the attributes of Dao, the emphasis on the "boundlessness" of Dao is more reasonable than other versions of texts such as Wang Bi's and the Silk text Lao Zi, in which we read that Dao is "changeless", creating thereby a contradictory situation between Dao's eternity and its dynamicity. On the one hand, the Confucian interpretation might put political and human considerations into ontological and cosmological considerations; on the other hand, it could also purify some cosmological texts by dropping some texts criticizing the Confucian concepts of Ren and the sage. The most evident Confucian intervention into The Guodian Lao Tzu could be found in the concepts of Virtue De) and Retracing View The concept of Virtue had lost its cosmological meaning and was reserved merely for describing human virtue. As to the concept of Guan, the retracing regard, which was applied to all things and even Dao itself in other texts, was limited to merely human social affairs and loses its cosmological meaning totally in Guodian's texts. (shrink)

本书包括“间性”的凸现——比较诗学与比较文化的多元主义与对话交往、寻找新的问题域——比较文学—比较文化的当代课题、西方与中国:二十世纪的语言论转向、西方当代作者中心论的兴起与衰落、西方当代文本中心论的 兴起与衰落等。.

漢宋分爭是清代學術的結穴，也制約着民國學術的流變。 本書以重新梳理清代漢宋關系為主旨，在盡量占據文獻的基礎上轉變研究思路，將清季以來尤其是民國學人名著中廣為流傳的觀點作為前賢見識，而非清學的本事；進而在整體的觀照下，選取漢宋敘述形成的關鍵環節，即阮元— —學海堂——陳澧的大事因緣，拋開成見，使條理人事關系與解讀文獻本意相輔相成，揭示史事、觀念發生演化的歷史進程，重現清中葉所謂漢宋分爭的本相，寓解構於重構之中。 於梅舫，1980年出生，浙江紹興人，歷史學博士。先后求學於浙江師范大學歷史系、中國人民大學歷史系、中山大學歷史系、復旦大學文史研究院，現為中山大學歷史系副教授。.

吴光辉,湖北省武汉市人,现为厦门大学外文学院讲师,日本语教育研究中心副主任。著有《传统与超越》。.